NRC-2694( —— )

Catalog No. M26774 CAS No. 936446-61-6

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Datasheet

HNMR

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MSDS

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Product Name

NRC-2694
Note

Research use only, not for human use.
Brief Description

NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.
Description

NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.(In Vitro):NRC-2694 (80 ng) induce comparable inhibition of EGFR expression.(In Vivo):NRC-2694 (10 mg/kg) regresses the tumor in mice. The maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (p.o.), in toxicity studies .
In Vitro

NRC-2694 at 80 ng (190 nm) concentrations causes comparable inhibition of EGFR expression.
In Vivo

In toxicity studies, the maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (po). NRC-2694 (10 mg/kg) regresses the tumor in mice.
Synonyms

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Pathway

Angiogenesis
Target

EGFR
Recptor

Influenza virus
Research Area

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Indication

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1.J V Tuttle, et al. Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents. J Med Chem

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