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NNK
CAS No. 64091-91-4
NNK( Nicotine-derived nitrosamine ketone )
Catalog No. M24655 CAS No. 64091-91-4
NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 146 | In Stock |
|
| 50MG | 215 | In Stock |
|
| 100MG | 260 | In Stock |
|
| 200MG | 385 | In Stock |
|
| 500MG | 617 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNNK
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NoteResearch use only, not for human use.
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Brief DescriptionNNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
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DescriptionNNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
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In VitroNNK (100 pM; 0-60 min) stimulates activation of PKCα and MAPKs ERK1/2 that directly induce c-Myc phosphorylation.NNK (100 pM; 96 hours) enhances proliferation of cells expressing WT but not AA c-Myc mutant. Western Blot Analysis Cell Line:NCI-H82 cells Concentration:100 pM Incubation Time:0-60 min Result:Stimulated activation of PKCα and MAPKs ERK1/2 that directly induced c-Myc phosphorylation.Apoptosis Analysis Cell Line:H1299 lung cancer cells Concentration:100 pM Incubation Time:96 hours Result:Enhanced proliferation of cells expressing WT but not T58A/S62A c-Myc mutant.
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In Vivo——
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SynonymsNicotine-derived nitrosamine ketone
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PathwayImmunology/Inflammation
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TargetLipoxygenase
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RecptorLOX
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Research Area——
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Indication——
Chemical Information
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CAS Number64091-91-4
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Formula Weight207.23
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Molecular FormulaC10H13N3O2
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESCN(CCCC(c1cnccc1)=O)N=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cheng G, Li J, Zheng M, Zhao Y, Zhou J, Li W. NNK, a tobacco-specific carcinogen, inhibits the expression of lysyl oxidase, a tumor suppressor. Int J Environ Res Public Health. 2014 Dec 23;12(1):64-82.
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