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NNC-711
CAS No. 145645-62-1
NNC-711( NNC711 )
Catalog No. M11968 CAS No. 145645-62-1
NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNNC-711
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NoteResearch use only, not for human use.
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Brief DescriptionNNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
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DescriptionNNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM; displays excellent selectivty over rGAT-2, hGAT-3 and hBGT-1, and other other neurotransmitter receptors; inhibits synaptosomal (IC50=47 nM), neuronal (IC50=1238 nM) and glial (IC50=636 nM) GABA uptake in vitro; demonstrates potent anticonvulsant activity against rodent seizures induced by DMCM.
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In Vitro——
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In Vivo——
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SynonymsNNC711
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PathwayMembrane Transporter/Ion Channel
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TargetGAT
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RecptorGAT
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Research Area——
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Indication——
Chemical Information
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CAS Number145645-62-1
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Formula Weight386.876
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Molecular FormulaC21H23ClN2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3.Cl
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Chemical Name1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Suzdak PD, et al. Eur J Pharmacol. 1992 Dec 2;224(2-3):189-98.
2. Oh DJ, et al. Epilepsia. 1994 Mar-Apr;35(2):426-30.
3. Borden LA, et al. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
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