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Home - Products - Membrane Transporter/Ion Channel - GAT - NNC-711

NNC-711

CAS No. 145645-62-1

NNC-711( NNC711 )

Catalog No. M11968 CAS No. 145645-62-1

NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NNC-711
  • Note
    Research use only, not for human use.
  • Brief Description
    NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
  • Description
    NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM; displays excellent selectivty over rGAT-2, hGAT-3 and hBGT-1, and other other neurotransmitter receptors; inhibits synaptosomal (IC50=47 nM), neuronal (IC50=1238 nM) and glial (IC50=636 nM) GABA uptake in vitro; demonstrates potent anticonvulsant activity against rodent seizures induced by DMCM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NNC711
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    145645-62-1
  • Formula Weight
    386.876
  • Molecular Formula
    C21H23ClN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3.Cl
  • Chemical Name
    1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Suzdak PD, et al. Eur J Pharmacol. 1992 Dec 2;224(2-3):189-98. 2. Oh DJ, et al. Epilepsia. 1994 Mar-Apr;35(2):426-30. 3. Borden LA, et al. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
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