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NMS-P645

CAS No. 1482518-95-5

NMS-P645( NMS P645 )

Catalog No. M12046 CAS No. 1482518-95-5

NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NMS-P645
  • Note
    Research use only, not for human use.
  • Brief Description
    NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.
  • Description
    NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively; exhibits excellent selectivity against a large panel of kinases; reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments; induces a significant anti-proliferative response in PCa cells combined with GDC-0941.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NMS P645
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    Pim
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1482518-95-5
  • Formula Weight
    512.095
  • Molecular Formula
    C28H38ClN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2-((S)-7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)-N-((S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Casuscelli F, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80. 2. Mologni L, et al. J Cancer. 2017 Jan 1;8(1):140-145.
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