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Home - Products - JAK/STAT Signaling - Pim - LGB-321

LGB-321

CAS No. 1210416-93-5

LGB-321( LGB 321 | LGB321 )

Catalog No. M10786 CAS No. 1210416-93-5

LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LGB-321
  • Note
    Research use only, not for human use.
  • Brief Description
    LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.
  • Description
    LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively; inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in PIM2-dependent MM cell lines; shows activity in cell lines derived from diverse hematological lineages, including ALL, AML, NHL; shows activity in the KG-1 AML xenograft model, and synergizes with cytarabine.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    LGB 321 | LGB321
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    Pim
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1210416-93-5
  • Formula Weight
    530.37
  • Molecular Formula
    C23H24Cl2F3N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=C(N2C[C@@H](N)[C@H](O)[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3.[H]Cl.[H]Cl
  • Chemical Name
    N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Garcia PD, et al. Clin Cancer Res. 2014 Apr 1;20(7):1834-45.
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