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ARN14974
CAS No. 1644158-57-5
ARN14974( —— )
Catalog No. M27444 CAS No. 1644158-57-5
ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | Get Quote |
|
| 5MG | 80 | Get Quote |
|
| 10MG | 125 | Get Quote |
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| 25MG | 242 | Get Quote |
|
| 50MG | 439 | Get Quote |
|
| 100MG | 626 | Get Quote |
|
| 200MG | 897 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameARN14974
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NoteResearch use only, not for human use.
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Brief DescriptionARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM.
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DescriptionARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM.
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In VitroARN14974 (20 μM; 24 hours;SW403 and Raw 264.7 cells) inhibits acid ceramidase (AC) in a complex cellular environment, leading to the intended biochemical response, that is, increased ceramide and decreased sphingosine levels.
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In VivoARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney.ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1644158-57-5
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Formula Weight404.441
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Molecular FormulaC24H21FN2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (123.63 mM)
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SMILESFc1ccc(cc1)-c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Min-Kyung Lee, et al. Tellimoside, a flavonol glycoside from Brasenia schreberi, inhibits the growth of cyanobacterium (Microcystis aeruginosa LB 2385). Journal of the Korean Society for Applied Biological Chemistry volume 56, pages 117-121 (2013).
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