NKY80
CAS No. 299442-43-6
NKY80 ( NKY 80;NKY-80 )
Catalog No. M13924 CAS No. 299442-43-6
A potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | Get Quote |
|
5MG | 56 | Get Quote |
|
10MG | 87 | Get Quote |
|
25MG | 177 | Get Quote |
|
50MG | 309 | Get Quote |
|
100MG | 471 | Get Quote |
|
200MG | 678 | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNKY80
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.
-
DescriptionA potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively; displays little to no activity for other AC isoforms (IC50>100 uM); blocks both BAPTA-AM-stimulated cAMP formation and renin release in primary cultures of juxtaglomerular cells.
-
SynonymsNKY 80;NKY-80
-
PathwayMetabolic Enzyme/Protease
-
TargetAdenylate Cyclase
-
RecptorAdenylate Cyclase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number299442-43-6
-
Formula Weight229.24
-
Molecular FormulaC12H11N3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1
-
Chemical Name2-amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Onda T, et al. J Biol Chem. 2001 Dec 21;276(51):47785-93.
2. Ortiz-Capisano MC, et al. Hypertension. 2007 Mar;49(3):618-24.
3. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.
2. Ortiz-Capisano MC, et al. Hypertension. 2007 Mar;49(3):618-24.
3. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.
molnova catalog
related products
-
NB 001
A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition).
-
CB-6673567
CB-6673567 is a potent, selective Adenylyl Cyclase 1 (AC1) inhibitor with IC50 of 77 uM.
-
SQ-22536
A potent, non-competitive Adenylyl Cyclase inhibitor with IC50 of 1.4 uM.