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NITD-564

CAS No. 1614262-75-7

NITD-564( NITD564 )

Catalog No. M12348 CAS No. 1614262-75-7

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NITD-564
  • Note
    Research use only, not for human use.
  • Brief Description
    NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.
  • Description
    NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb; binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NITD564
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1614262-75-7
  • Formula Weight
    283.371
  • Molecular Formula
    C18H21NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    6-(cyclohexylmethyl)-4-hydroxy-3-phenylpyridin-2(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.
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