TCA-1 ( TCA1 )

Catalog No. M16276 CAS No. 864941-32-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TCA-1
Note

Research use only, not for human use.
Brief Description

A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models.
Description

A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.
Synonyms

TCA1
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

864941-32-2
Formula Weight

375.42
Molecular Formula

C16H13N3O4S2
Purity

>98% (HPLC)
Solubility

DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CCOC(=O)NC(=O)C1=C(SC=C1)NC(=O)C2=NC3=CC=CC=C3S2
Chemical Name

ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate

1. Wang F, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7.

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