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NITD-349

CAS No. 1473450-62-2

NITD-349 ( NITD349 )

Catalog No. M12026 CAS No. 1473450-62-2

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv.

Purity : >98% (HPLC)

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HPLC

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Size	Price / USD	Stock	Quantity
2MG	41	Get Quote
5MG	65	Get Quote
10MG	110	Get Quote
25MG	200	Get Quote
50MG	335	Get Quote
100MG	500	Get Quote
500MG	1098	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

NITD-349
Note

Research use only, not for human use.
Brief Description

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv.
Description

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv; shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb; demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models.
Synonyms

NITD349
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

——

Chemical Information

CAS Number

1473450-62-2
Formula Weight

306.36
Molecular Formula

C17H20F2N2O
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 310 mg/mL 1011.91 mM
SMILES

CC1(CCC(CC1)NC(=O)C2=CC3=C(N2)C=C(C=C3F)F)C
Chemical Name

N-(4,4-dimethylcyclohexyl)-4,6-difluoro-1H-indole-2-carboxamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Rao SP, et al. Sci Transl Med. 2013 Dec 4;5(214):214ra168.

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