Calcimycin
CAS No. 52665-69-7
Calcimycin ( A-23187,Antibiotic A-23187 )
Catalog No. M22570 CAS No. 52665-69-7
Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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5MG | 269 | In Stock |
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Biological Information
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Product NameCalcimycin
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NoteResearch use only, not for human use.
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Brief DescriptionCalcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?
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DescriptionCalcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.Calcimycin (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
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SynonymsA-23187,Antibiotic A-23187
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorBacterial;Antifungal;Apoptosis;Autophagy;Antibiotic
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Research Area——
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Indication——
Chemical Information
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CAS Number52665-69-7
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Formula Weight523.62
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Molecular FormulaC29H37N3O6
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Purity>98% (HPLC)
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SolubilityDMSO:47 mg/mL (89.76mM; Need ultrasonic)
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SMILES[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c1ccc[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82.
molnova catalog
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