Calcimycin

CAS No. 52665-69-7

Calcimycin ( A-23187,Antibiotic A-23187 )

Catalog No. M22570 CAS No. 52665-69-7

Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Calcimycin
  • Note
    Research use only, not for human use.
  • Brief Description
    Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?
  • Description
    Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.Calcimycin (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
  • Synonyms
    A-23187,Antibiotic A-23187
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial;Antifungal;Apoptosis;Autophagy;Antibiotic
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    52665-69-7
  • Formula Weight
    523.62
  • Molecular Formula
    C29H37N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:47 mg/mL (89.76mM; Need ultrasonic)
  • SMILES
    [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c1ccc[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82.
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