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NH-3
CAS No. 447415-26-1
NH-3 ( —— )
Catalog No. M28312 CAS No. 447415-26-1
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 520 | Get Quote |
|
| 10MG | 750 | Get Quote |
|
| 25MG | 1143 | Get Quote |
|
| 50MG | 1521 | Get Quote |
|
| 100MG | 2061 | Get Quote |
|
| 500MG | 4158 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNH-3
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NoteResearch use only, not for human use.
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Brief DescriptionNH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.
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DescriptionNH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.(In Vivo):NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose .
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetTHR
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RecptorNa+/Ca2+ Exchanger
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Research Area——
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Indication——
Chemical Information
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CAS Number447415-26-1
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Formula Weight473.5
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Molecular FormulaC28H27NO6
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)C1=CC(CC2=C(C)C=C(OCC(O)=O)C=C2C)=CC(C#CC2=CC=C(C=C2)[N+]([O-])=O)=C1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ohara F, et al. Preischemic and postischemic treatment with a new Na+/H+-exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion. J Cardiovasc Pharmacol. 1999 Dec;34(6):848-56.
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NH-3
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.
