Cart
sales@molnova.com
Home - Products - Angiogenesis - CDK - HQ461

HQ461

CAS No. 1226443-41-9

HQ461( —— )

Catalog No. M28932 CAS No. 1226443-41-9

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
2MG 51 In Stock
5MG 85 In Stock
10MG 147 In Stock
25MG 337 In Stock
50MG 555 In Stock
100MG 792 In Stock
200MG Get Quote In Stock
500MG 1609 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    HQ461
  • Note
    Research use only, not for human use.
  • Brief Description
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
  • Description
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
  • In Vitro
    Western Blot Analysis Cell Line:A549 cells Concentration:10 μM Incubation Time:0-8h Result:Induces 50% reduction of CDK12 protein level at 8 h, and>8 fold reduction of the CCNK protein level at 4 h.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1226443-41-9
  • Formula Weight
    345.44
  • Molecular Formula
    C15H15N5OS2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (180.93 mM)
  • SMILES
    Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ML133 HCl

    ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.

  • 4-Methoxybenzoic aci...

    4-Methoxybenzoic acid could be used as raw material in cosmetic and dermatologic products and/or aroma components in foodstuffs, it has antiinflammatory and antimicrobial activities.

  • MBQ-167

    MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).

Sign In Join Free