NDMC101

CAS No. 1308631-40-4

NDMC101 ( —— )

Catalog No. M22188 CAS No. 1308631-40-4

NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 34 In Stock
5MG 55 In Stock
10MG 91 In Stock
25MG 186 In Stock
50MG 295 In Stock
100MG 441 In Stock
500MG 981 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    NDMC101
  • Note
    Research use only, not for human use.
  • Brief Description
    NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?
  • Description
    NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?Moreover, pit formation assay showed that NDMC101 significantly reduced the bone-resorbing activity of mature osteoclasts[1].In CIA mice, oral administration of NDMC101 reduced arthritic index and mitigated bone erosion.?Serum TNF-α and IL-1β concentrations in these mice were decreased significantly at the higher dose of 62.5 mg/kg.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    osteoclastogenesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1308631-40-4
  • Formula Weight
    265.66
  • Molecular Formula
    C13H9ClFNO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Oc1ccccc1C(=O)Nc1ccc(Cl)cc1F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cheng C P , Huang H S , Hsu Y C , et al. A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis.[J]. Journal of Clinical Immunology, 2012, 32(4):762-777.
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