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NDMC101
CAS No. 1308631-40-4
NDMC101 ( —— )
Catalog No. M22188 CAS No. 1308631-40-4
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
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| 5MG | 55 | In Stock |
|
| 10MG | 91 | In Stock |
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| 25MG | 186 | In Stock |
|
| 50MG | 295 | In Stock |
|
| 100MG | 441 | In Stock |
|
| 500MG | 981 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNDMC101
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NoteResearch use only, not for human use.
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Brief DescriptionNDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?
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DescriptionNDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?Moreover, pit formation assay showed that NDMC101 significantly reduced the bone-resorbing activity of mature osteoclasts[1].In CIA mice, oral administration of NDMC101 reduced arthritic index and mitigated bone erosion.?Serum TNF-α and IL-1β concentrations in these mice were decreased significantly at the higher dose of 62.5 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorosteoclastogenesis
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Research Area——
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Indication——
Chemical Information
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CAS Number1308631-40-4
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Formula Weight265.66
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Molecular FormulaC13H9ClFNO2
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Purity>98% (HPLC)
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Solubility——
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SMILESOc1ccccc1C(=O)Nc1ccc(Cl)cc1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cheng C P , Huang H S , Hsu Y C , et al. A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis.[J]. Journal of Clinical Immunology, 2012, 32(4):762-777.
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