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Home - Products - Endocrinology/Hormones - ATPase - NDI-091143

NDI-091143

CAS No. 2375840-87-0

NDI-091143 ( —— )

Catalog No. M20771 CAS No. 2375840-87-0

NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay)indirectly disrupting citrate binding via an unexpected mechanism of inhibition.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NDI-091143
  • Note
    Research use only not for human use.
  • Brief Description
    NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay)indirectly disrupting citrate binding via an unexpected mechanism of inhibition.
  • Description
    NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay)indirectly disrupting citrate binding via an unexpected mechanism of inhibition.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    ACLY
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    2375840-87-0
  • Formula Weight
    453.8
  • Molecular Formula
    C20H14ClF2NO5S?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:91 mg/mL (200.51 mM)
  • SMILES
    COC(=O)c1cc(Cl)c(O)c(S(=O)(=O)Nc2cc(-c3ccccc3)c(F)cc2F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jia Wei Silvana et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase[J]. Nature 2019.
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