Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - NCT-502

NCT-502

CAS No. 1542213-00-2

NCT-502( N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide )

Catalog No. M26771 CAS No. 1542213-00-2

NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 30 Get Quote
5MG 47 Get Quote
10MG 71 Get Quote
25MG 146 Get Quote
50MG 228 Get Quote
100MG 393 Get Quote
500MG 884 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    NCT-502
  • Note
    Research use only, not for human use.
  • Brief Description
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.
  • Description
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.(In Vitro):NCT-502 is cytotoxic to MDA-MB-468 (EC50: 15.2 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    Crimean-Congo hemorrhagic fever virus (CCHFV)| Nucleoside Antimetabolite/Analog
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1542213-00-2
  • Formula Weight
    395.45
  • Molecular Formula
    C18H20F3N5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 130 mg/mL (328.74 mM)
  • SMILES
    Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Mutant IDH1 inhibito...

    Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).

  • Nitrophenide

    Nitrophenide inhibits mannitol-1-phosphate dehydrogenase (M1PDH), which catalyzes the committed enzymatic step in the mannitol cycle. Nitrophenide can be used as an anticoccidial agent.

  • DHODH-IN-15

    DHODH-IN-15 is the hydroxyfuran analogue of A771726.

Sign In Join Free