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NCT-502

CAS No. 1542213-00-2

NCT-502 ( N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide )

Catalog No. M26771 CAS No. 1542213-00-2

NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 30 Get Quote
5MG 47 Get Quote
10MG 71 Get Quote
25MG 146 Get Quote
50MG 228 Get Quote
100MG 393 Get Quote
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Biological Information

  • Product Name
    NCT-502
  • Note
    Research use only, not for human use.
  • Brief Description
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.
  • Description
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.(In Vitro):NCT-502 is cytotoxic to MDA-MB-468 (EC50: 15.2 μM).
  • Synonyms
    N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    Crimean-Congo hemorrhagic fever virus (CCHFV); Nucleoside Antimetabolite/Analog
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1542213-00-2
  • Formula Weight
    395.5
  • Molecular Formula
    C18H20F3N5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
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