Cart
sales@molnova.com
DHODH-IN-15
CAS No. 1364791-88-7
DHODH-IN-15 ( —— )
Catalog No. M26156 CAS No. 1364791-88-7
DHODH-IN-15 is the hydroxyfuran analogue of A771726.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | Get Quote |
|
| 5MG | 402 | Get Quote |
|
| 10MG | 593 | Get Quote |
|
| 25MG | 888 | Get Quote |
|
| 50MG | 1242 | Get Quote |
|
| 100MG | 1701 | Get Quote |
|
| 500MG | 3411 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameDHODH-IN-15
-
NoteResearch use only, not for human use.
-
Brief DescriptionDHODH-IN-15 is the hydroxyfuran analogue of A771726.
-
DescriptionDHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.(In Vitro):DHODH-IN-15 is a hydroxyfuran analogue of A771726, in which the biphenyl skeleton does not carry any substituents. Turning to the derivative DHODH-IN-15, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, DHODH-IN-15 was found to bind in a BQN-like manner, ie, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. On 1D3G and 1UUO, in any case, no interaction of Tyr356 with Leflunomide was found, but when 2BXV was used as a docking target, a large part of this posture was found.
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetDehydrogenase
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1364791-88-7
-
Formula Weight281.3
-
Molecular FormulaC15H11N3O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(Nc1ccc(cc1)-c1ccccc1)c1no[nH]c1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Issara-Amphorn et al. Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis. J Innate Immun. 2020;12(6):461-479.
molnova catalog
related products
-
hDHODH-IN-3
hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.
-
CHIKV-IN-2
CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools.
-
AGI-5198
AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.
