
NCGC00378430
CAS No. 920650-00-6
NCGC00378430( —— )
Catalog No. M24968 CAS No. 920650-00-6
NCGC00378430 is a potent?SIX1/EYA2?interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 178 | In Stock |
![]() ![]() |
10MG | 295 | In Stock |
![]() ![]() |
25MG | 502 | In Stock |
![]() ![]() |
50MG | 709 | In Stock |
![]() ![]() |
100MG | 1008 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameNCGC00378430
-
NoteResearch use only, not for human use.
-
Brief DescriptionNCGC00378430 is a potent?SIX1/EYA2?interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
-
DescriptionNCGC00378430 is a potent?SIX1/EYA2?interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
-
In VitroWestern Blot Analysis Cell Line:T47D cells Concentration:20 μM Incubation Time:3 days Result:Blocked TGF-β induced activation of p-Smad3, upregulation of FN1, and downregulation of E-CAD.
-
In VivoAnimal Model:6-8 week old NSG mice with MCF7 tumor cellsDosage:25 mg/kg Administration:Local Injection to the site of tumor; every other day; from day 3 until the day 21 Result:Dramatically decreased distant metastatic burden compared to vehicle treatment.Had no growth inhibitory effect.Animal Model:Mice Dosage:20 mg/kg (Pharmacokinetic Analysis) Administration:IV Result:Had a T1/2α of 0.25 hours, a CL of 6.19 L/hr?kg, a Vss of 4.08 L/kg, a Cmax of 6703 ng/mL and an AUC of 3234 ng/mL?hr.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorSIX1-EYA2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number920650-00-6
-
Formula Weight441.5
-
Molecular FormulaC22H23N3O5S
-
Purity>98% (HPLC)
-
SolubilityDMSO:90 mg/mL?(203.85 mM;?Need ultrasonic)
-
SMILESO=C(NC1=CC=C(OC)C(S(=O)(N2CCOCC2)=O)=C1)C3=CC=CC(N4C=CC=C4)=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference



-
SMA-12b
SMA-12b is an analog of the immunomodulatory parasite product ES-62 that has immunomodulatory activity, can modify the expression of many inflammatory response genes.
-
Ciamexon
Ciamexon (Ciamexone) is a novel immunomodulator that has shown promising results in experimental models of autoimmune disease with little demonstrated cytotoxicity.
-
Epithalon TFA
Epitalon TFA is an anti-aging agent and telomerase activator.Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.