Cart
sales@molnova.com
NC-005
CAS No. 1237540-74-7
NC-005( NC 005 | NC005 )
Catalog No. M10955 CAS No. 1237540-74-7
A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNC-005
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
-
DescriptionA potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM.
-
In Vitro——
-
In Vivo——
-
SynonymsNC 005 | NC005
-
PathwayProteasome/Ubiquitin
-
TargetProteasome
-
RecptorProteasome
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1237540-74-7
-
Formula Weight663.815
-
Molecular FormulaC40H45N3O6
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name(S)-3-(4-methoxyphenyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-(2-(naphthalen-2-yl)acetamido)propanamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89.
2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.
molnova catalog
related products
-
NC-005
A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
-
MUN57694
MUN57694 is an inhibitor of 26S proteasome.
-
Oprozomib
Oprozomib (ONX-0912;PR-047) is a potent, orally bioavailable proteasome inhibitor that inhibits chymotrypsin-like (CT-L) activity of 20S proteasome β5/LMP7 with IC50 of 36/82 nM.
