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N106

CAS No. 862974-25-2

N106 ( N-106; N 106 )

Catalog No. M27902 CAS No. 862974-25-2

N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    N106
  • Note
    Research use only, not for human use.
  • Brief Description
    N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.
  • Description
    N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.(In Vitro):N106 (10?min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24?h in cardiomyocytes.(In Vivo):N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10?mg/kg; i.v.) exhibits a half-life of 65.4?min and a Cmax of ～2.24?μM.
  • Synonyms
    N-106; N 106
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HD1-A;HD1-B;HD2;HDAC1;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9;HDAC10;HDAC11
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    862974-25-2
  • Formula Weight
    354.4
  • Molecular Formula
    C17H14N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zappasodi R, et al. Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas. Int J Cancer. 2014 Nov 1;135(9):2034-45.
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