5α-Pregnane-3β,6α-diol-20-one

Research use only, not for human use.

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone. It can be produced in starved androgen-responsive prostate cancer cells.

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone. It can be produced in starved androgen-responsive prostate cancer cells.

Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity.

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Others

Other Targets

Others

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21853-11-2

334.49

C21H34O3

>98% (HPLC)

DMSO:100 mg/mL (298.96 mM; Need ultrasonic)

C[C@@]12[C@]3([H])[C@](C[C@H](O)[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@@H](C(C)=O)CC4)CC3

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(-20℃)

With Ice Pack

≥ 2 years