N-Desalkylflurazepam( Norfludiazepam )

Catalog No. M28291 CAS No. 2886-65-9

N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

N-Desalkylflurazepam
Note

Research use only, not for human use.
Brief Description

N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.
Description

N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.(In Vitro):Flurazepam's long-acting metabolite, N-Desalkylflurazepam, reduces the amplitudes of all the evoked potentials (EPs) components .
In Vitro

Flurazepam's long-acting metabolite, N-Desalkylflurazepam, reduces the amplitudes of all the evoked potentials (EPs) components.
In Vivo

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Synonyms

Norfludiazepam
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

S-adenosylmethionine decarboxylase (SAMDC)
Research Area

——
Indication

——

Chemical Information

CAS Number

2886-65-9
Formula Weight

288.71
Molecular Formula

C15H10ClFN2O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (346.38 mM)
SMILES

Fc1ccccc1C1=NCC(=O)Nc2ccc(Cl)cc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.

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