N-Acetyl-β-Asp-Glu

Research use only, not for human use.

Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid).

Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. Thus it is used in allergic conditions such as allergic conjunctivitis.

β-Spaglumic acid (63-1000 μM; 2 h) protects against NMDA-induced injury of spinal cord cells in a dose-dependent manner.β-Spaglumic acid (0-1000 μM; 2 h) protects spinal cord cells against hypoxia.β-Spaglumic acid (500 μM) significantly reduces intraneuronal free Ca2+ responses upon neuronal exposure to 25 μM NMDA.β-Spaglumic acid (100 μM; 7 min) antagonizes mGluR3 in cerebellar granule cells. Cell Viability Assay Cell Line:Spinal cord cells (NMDA-induced) (from spinal cords removed from prenatal day 15 Sprague-Dawley rat fetuses)Concentration:63-1000 μM Incubation Time:2 h Result:Led to a significant attenuation of NMDA toxicity at a concentration of 63 μM and completely blocked NMDA toxicity with 500 and 1000 μM concentrations.Apparently minimized the basal loss of cell viability associated with experimental handling of the cells (e.g. serum removal, media changes).Cell Viability Assay Cell Line:Spinal cord cells (hypoxic-induced)Concentration:0-1000 μM Incubation Time:2 h Result:Provided 75% protection during hypoxia when at 8 μM and completely eliminated hypoxia-induced loss of viability (107.4-114.4% protection, respectively) when at 63-1000 μM.Cell Viability Assay Cell Line:Cerebellar granule cells (expressing group I-III mGluRs)Concentration:100 μM Incubation Time:7 minResult:Blocked NAAG inhibition of forskolin-stimulated cAMP formation via mGluR3.

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Spaglumic Acid | Naaxia

Others

Other Targets

Amino Acids and Derivatives

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4910-46-7

304.25

C11H16N2O8

>98% (HPLC)

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CC(=O)N[C@@H](CC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O

(S)-1-(((S)-3-acetamido-3-(carboxyoxy)propyl)amino)propane-1,3-diyl bis(hydrogen carbonate)

(-20℃)

With Ice Pack

≥ 2 years