
N-Acetyl-5-hydroxytryptamine
CAS No. 1210-83-9
N-Acetyl-5-hydroxytryptamine( N-Acetyl-5-hydroxytryptamine | NAS )
Catalog No. M10787 CAS No. 1210-83-9
N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin.
Purity : >98% (HPLC)






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Biological Information
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Product NameN-Acetyl-5-hydroxytryptamine
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NoteResearch use only, not for human use.
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Brief DescriptionN-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin.
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DescriptionN-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase.
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In VitroN-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner.
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In VivoTo explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation.
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SynonymsN-Acetyl-5-hydroxytryptamine | NAS
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorSert (Sodium-dependent)
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Research Area——
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Indication——
Chemical Information
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CAS Number1210-83-9
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Formula Weight218.25
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Molecular FormulaC12H14N2O2
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESCC(=O)NCCC1=CNC2=C1C=C(O)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jang SW, et al. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3876-8
molnova catalog



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