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Levodropropizine

CAS No. 99291-25-5

Levodropropizine( Levodropropizine | DF 526 | DF-526 | DF526 | Levotuss )

Catalog No. M16909 CAS No. 99291-25-5

Levodropropizine is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Levodropropizine
  • Note
    Research use only, not for human use.
  • Brief Description
    Levodropropizine is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.
  • Description
    Levodropropizine is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Pentylenetetrazol (PTZ)-induced status epilepticus in rats Dosage:20 and 40 mg/kg Administration:i.p.Result:Decreased Mean electroencephalogram (EEG) spike wave percentage score from 76.8% (placebo) to 13.1% (lower dose) and 7.6% (higher dose).Decreased Racine's Convulsion Scale (RCS) from a mean of 5.8 (placebo) to 1.83 (lower dose) and 1.16 (higher dose). Increased time to first myoclonic jerk (TFMJ) from a mean of 65.1 s (placebo), to 247.3 s (lower dose) and 295.5 s (higher dose).
  • Synonyms
    Levodropropizine | DF 526 | DF-526 | DF526 | Levotuss
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    HT
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    99291-25-5
  • Formula Weight
    236.31
  • Molecular Formula
    C13H20N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 47 mg/mL (198.89 mM); Water: 15 mg/mL (63.47 mM); DMSO: 47 mg/mL (198.89 mM)
  • SMILES
    OC[C@@H](O)CN1CCN(C2=CC=CC=C2)CC1
  • Chemical Name
    (S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Melillo G, et al. Arzneimittelforschung, 1988, 38(8), 1144-1150.
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