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Myricetin
CAS No. 529-44-2
Myricetin( Cannabiscetin | NSC 407290 )
Catalog No. M14876 CAS No. 529-44-2
Myricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids.
Purity : >98% (HPLC)
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Size | Price / USD | Stock | Quantity |
25MG | 33 | In Stock |
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50MG | 50 | In Stock |
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100MG | 68 | In Stock |
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500MG | 158 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameMyricetin
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NoteResearch use only, not for human use.
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Brief DescriptionMyricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids.
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DescriptionMyricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids. Dihydromyricetin is frequently sold as a supplement and has controversial function as a partial GABAA receptor potentiator and treatment in Alcohol Use Disorder (AUD). (In Vitro):Myricetin exhibits the scavenging activity towards a number of radicals and ions. It displays poor activity (IC50 value=1.4 mg/mL) in a superoxide dismutase (SOD)-like activity assay. It prevents cancer cell death via apoptosis via regulation of PI3K/Akt and MAPK signalling pathways. Myricetin exhibits antiphotoaging effects by quenching causative free radicals in the skin. Myricetin is able to suppress UVB-induced COX-2 expression in mouse skin epidermal JB6 P+ cells. It inhibits UVB-induced initiation of activator protein-1 and NF-κβ, as well as Fyn kinase activity. Myricetin inhibits viability of SKOV3 ovarian cancer cells in a dose-dependent manner. It induces DNA DSBs and ER stress, which leads to apoptosis in SKOV3 cells. Myricetin inhibits human Hsp70 by more than 80% with IC50 values of 83, 11 and 12 μM, respectively.(In Vivo):Treatment of orthotopic pancreatic tumors with myricetin results in tumor regression and decreases metastatic spread. Exposure to 150 μM myricetin causes 14%, 26%, 5% and 49% inhibition of rabbit platelet aggregation, induced by ADP, arachidonic acid, collagen and PAF, respectively.
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In Vitro——
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In Vivo——
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SynonymsCannabiscetin | NSC 407290
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kγ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number529-44-2
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Formula Weight318.24
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Molecular FormulaC15H10O8
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Purity>98% (HPLC)
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SolubilityEthanol: 20 mg/mL warmed (62.84 mM); DMSO: 63 mg/mL (197.96 mM)
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SMILESO=C1C(O)=C(C2=CC(O)=C(O)C(O)=C2)OC3=C1C(O)=CC(O)=C3
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Chemical Name3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Flamini R, et al. Int J Mol Sci. 2013 Sep 27;14(10):19651-69.
molnova catalog
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