Myokinasib( —— )

Catalog No. M17042 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Myokinasib
Note

Research use only, not for human use.
Brief Description

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM.
Description

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex; Myokinasib inhibits only two additional kinases PLK2/3 with IC50 of 10.3/6.7 uM in a panel of 25 kinases, does not bind to the Polo-box domain of PLK2 and PLK3; impairs cytokinesis, induces formation of multinucleated cells, and reduces phosphorylated myosin II light chain abundance on stress fibers, reduces phospho-S19-MLC protein levels in cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Myosin
Recptor

Myosin
Research Area

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Indication

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CAS Number

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Formula Weight

402.538
Molecular Formula

C26H30N2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

ethyl (6R,7R,8S,9R)-8-(2,6-dimethylphenyl)-6,7-dimethyl-6,7,8,10-tetrahydro-6,9-epiminocyclohepta[b]indole-9(5H)-carboxylate

1. Schneidewind T, et al. Cell Chem Biol. 2018 Dec 11. pii: S2451-9456(18)30436-7.

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