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MitoBloCK-10

CAS No. 394694-98-5

MitoBloCK-10( 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m )

Catalog No. M22749 CAS No. 394694-98-5

MitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MitoBloCK-10
  • Note
    Research use only, not for human use.
  • Brief Description
    MitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
  • Description
    MitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
  • In Vitro
    Cell Viability Assay Cell Line:A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.Concentration:100 μM.Incubation Time:30 min.Result:WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil.Cell Viability Assay Cell Line:HeLa cells.Concentration:0-100 μM.Incubation Time:24 h.Result:Inhibited HeLa cells vibility, with an IC50 of 17.2 μM.
  • In Vivo
    ——
  • Synonyms
    3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    394694-98-5
  • Formula Weight
    293.28
  • Molecular Formula
    C12H8FN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (426.23 mM)
  • SMILES
    [O-][N+](=O)c1ccc(\C=N\NC(=O)c2cccc(F)c2)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442.
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