
Miridesap
CAS No. 224624-80-0
Miridesap( Ro 638695 | GSK-2315698 | CPHPC )
Catalog No. M13606 CAS No. 224624-80-0
Miridesap (Ro 638695;GSK-2315698;CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils.
Purity : >98% (HPLC)






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Biological Information
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Product NameMiridesap
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NoteResearch use only, not for human use.
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Brief DescriptionMiridesap (Ro 638695;GSK-2315698;CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils.
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DescriptionMiridesap (Ro 638695;GSK-2315698;CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils; crosslinks and dimerizes SAP molecules, leading to their very rapid clearance by the liver, and thus produces a marked depletion of circulating human SAP; Miridesap is a novel therapeutic approach to both systemic amyloidosis and diseases associated with local amyloid, including Alzheimer's disease and type 2 diabetes.Alzheimer Disease Phase 2 Clinical(In Vitro):Miridesap is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles. Miridesap depletes circulating SAP almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies.
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In VitroMiridesap is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles. Miridesap depletes circulating SAP almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies.
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In Vivo——
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SynonymsRo 638695 | GSK-2315698 | CPHPC
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PathwayOthers
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TargetAmyloids
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RecptorAmyloids
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number224624-80-0
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Formula Weight340.376
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Molecular FormulaC16H24N2O6
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Purity>98% (HPLC)
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SolubilityDMSO : 75 mg/mL 220.35 mM
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SMILESO=C(N1[C@H](CCC1)C(O)=O)CCCCC(N2[C@H](CCC2)C(O)=O)=O
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Chemical Name1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kolstoe SE, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23.
2. Pepys MB, et al. Nature. 2002 May 16;417(6886):254-9.
molnova catalog



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