Miridesap

CAS No. 224624-80-0

Miridesap( Ro 638695 | GSK-2315698 | CPHPC )

Catalog No. M13606 CAS No. 224624-80-0

Miridesap (Ro 638695;GSK-2315698;CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 In Stock
10MG 59 In Stock
25MG 115 In Stock
50MG 173 In Stock
100MG 258 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Miridesap
  • Note
    Research use only, not for human use.
  • Brief Description
    Miridesap (Ro 638695;GSK-2315698;CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils.
  • Description
    Miridesap (Ro 638695;GSK-2315698;CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils; crosslinks and dimerizes SAP molecules, leading to their very rapid clearance by the liver, and thus produces a marked depletion of circulating human SAP; Miridesap is a novel therapeutic approach to both systemic amyloidosis and diseases associated with local amyloid, including Alzheimer's disease and type 2 diabetes.Alzheimer Disease Phase 2 Clinical(In Vitro):Miridesap is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles. Miridesap depletes circulating SAP almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies.
  • In Vitro
    Miridesap is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles. Miridesap depletes circulating SAP almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies.
  • In Vivo
    ——
  • Synonyms
    Ro 638695 | GSK-2315698 | CPHPC
  • Pathway
    Others
  • Target
    Amyloids
  • Recptor
    Amyloids
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    224624-80-0
  • Formula Weight
    340.376
  • Molecular Formula
    C16H24N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 75 mg/mL 220.35 mM
  • SMILES
    O=C(N1[C@H](CCC1)C(O)=O)CCCCC(N2[C@H](CCC2)C(O)=O)=O
  • Chemical Name
    1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kolstoe SE, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23. 2. Pepys MB, et al. Nature. 2002 May 16;417(6886):254-9.
molnova catalog
related products
  • CID 9998128

    CID 9998128 is a potential multi-target drug for the Alzheimer's disease (AD).

  • TRX-0237 Methylate

    TRX-0237 Methylate (LMTX) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.

  • TDI-2760

    TDI-2760 si a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction.