(R)-Terazosin
CAS No. 109351-34-0
(R)-Terazosin ( —— )
Catalog No. M22490 CAS No. 109351-34-0
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 177 | In Stock |
|
10MG | 259 | In Stock |
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25MG | 437 | In Stock |
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50MG | 624 | In Stock |
|
100MG | 888 | In Stock |
|
200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name(R)-Terazosin
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NoteResearch use only, not for human use.
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Brief Description(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively).
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Description(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively). (R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor(Ki of 3.85 μM, 0.33 μM and 0.37 μM, respectively). (R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues.(R)-Terazosin shows antagonism of at rat atrial α2B receptor (pEC30 : 5.69). (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor (pA2 of 7.5 and 5.31, respectively).
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Synonyms——
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PathwayAngiogenesis
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TargetAdrenergic Receptor
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Recptorα1a-adrenoceptor;α1b-adrenoceptor ;α1d-adrenoceptor
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Research Area——
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Indication——
Chemical Information
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CAS Number109351-34-0
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Formula Weight387.43
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Molecular FormulaC19H25N5O4
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Purity>98% (HPLC)
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SolubilityDMSO:75 mg/mL (193.58 mM; Need ultrasonic)
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SMILESCOc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)[C@H]1CCCO1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hancock AA, et al. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res. 1995 Sep-Dec;15(7-8):863-85.
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