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Mildronate

CAS No. 76144-81-5

Mildronate( Meldonium | Kvaterin | Mildronate | Quaterin )

Catalog No. M15892 CAS No. 76144-81-5

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mildronate
  • Note
    Research use only, not for human use.
  • Brief Description
    Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
  • Description
    Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
  • In Vitro
    RT-PCR Cell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator Concentration:20, or 40 μM Incubation Time:24 h Result:Significantly decreased the mRNA expression of PFKP, PDK1, and PKM2 compared with the hypoxia group.Western Blot Analysis Cell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator Concentration:20, or 40 μM Incubation Time:24 h Result:Significantly reduced the protein expression of PFKP, PKM2, and LDHA.
  • In Vivo
    ——
  • Synonyms
    Meldonium | Kvaterin | Mildronate | Quaterin
  • Pathway
    Immunology/Inflammation
  • Target
    Hydroxylase
  • Recptor
    Dopamine β-hydroxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    76144-81-5
  • Formula Weight
    146.19
  • Molecular Formula
    C6H14N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in Water
  • SMILES
    O=C([O-])CCN[N+](C)(C)C
  • Chemical Name
    3-(2,2,2-Trimethylhydrazine)propionate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zvejniece, L et al.Behavioral Pharmacology. 21: 548–555.
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