
Metyrapone
CAS No. 54-36-4
Metyrapone( NSC 25265 | SU 4885 )
Catalog No. M14949 CAS No. 54-36-4
Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
100MG | 43 | In Stock |
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200MG | 71 | In Stock |
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500MG | 133 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameMetyrapone
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NoteResearch use only, not for human use.
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Brief DescriptionMetyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
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DescriptionMetyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.(In Vitro):Metyrapone (100?μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress.(In Vivo):Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley rats (n=179; 270-300g)Dosage:25 or 50 mg/kg (in a volume of 2.0 mL/kg) Administration:SC, single dosage Result:Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
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SynonymsNSC 25265 | SU 4885
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PathwayOthers
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TargetOther Targets
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RecptorCamphor 5-monooxygenase
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number54-36-4
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Formula Weight226.27
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Molecular FormulaC14H14N2O
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Purity>98% (HPLC)
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Solubilitysparingly soluble in Water
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SMILESCC(C1=CC=CN=C1)(C)C(C2=CC=CN=C2)=O
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Chemical Name2-methyl-1,2-dipyridin-3-ylpropan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shiro Y, et al. Biochemistry. 1995 Jul 18;34(28):9052-8.
molnova catalog



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