Cart
sales@molnova.com
Metyrapone
CAS No. 54-36-4
Metyrapone( NSC 25265 | SU 4885 )
Catalog No. M14949 CAS No. 54-36-4
Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 43 | In Stock |
|
| 200MG | 71 | In Stock |
|
| 500MG | 133 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMetyrapone
-
NoteResearch use only, not for human use.
-
Brief DescriptionMetyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
-
DescriptionMetyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.(In Vitro):Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress.(In Vivo):Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage.
-
In Vitro——
-
In VivoAnimal Model:Male Sprague-Dawley rats (n=179; 270-300g)Dosage:25 or 50 mg/kg (in a volume of 2.0 mL/kg) Administration:SC, single dosage Result:Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
-
SynonymsNSC 25265 | SU 4885
-
PathwayOthers
-
TargetOther Targets
-
RecptorCamphor 5-monooxygenase
-
Research AreaMetabolic Disease
-
Indication——
Chemical Information
-
CAS Number54-36-4
-
Formula Weight226.27
-
Molecular FormulaC14H14N2O
-
Purity>98% (HPLC)
-
Solubilitysparingly soluble in Water
-
SMILESCC(C1=CC=CN=C1)(C)C(C2=CC=CN=C2)=O
-
Chemical Name2-methyl-1,2-dipyridin-3-ylpropan-1-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Shiro Y, et al. Biochemistry. 1995 Jul 18;34(28):9052-8.
molnova catalog
related products
-
Fluorescein di-beta-...
Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λem=535 nm, λex=485 nm).
-
Sodium Hyaluronate
Hyaluronic acid (HA) is an anionic nonsulfated glycosaminoglycan distributed widely throughout connective epithelial and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated forms in the plasma membrane instead of the Golgi and can be very large with its molecular weight often reaching the millions.
-
EAAT2 activator 1
F2005-0304 is a thiopyridazine derivative that has been found to increase EAAT2 protein levels in astrocytes.
