
Methylprednisolone
CAS No. 83-43-2
Methylprednisolone( Medesone | Medrol | Noretona | NSC 19987 | U 7532 )
Catalog No. M16092 CAS No. 83-43-2
Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
Purity : >98% (HPLC)






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Biological Information
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Product NameMethylprednisolone
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NoteResearch use only, not for human use.
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Brief DescriptionMethylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
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DescriptionMethylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.(In Vitro):Methylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Methylprednisolone is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used for vestibular neuritis . After six months the patients who were treated with methylprednisolone within eight hours of their injury had significant improvement as compared with those given placebo in motor function (neurologic change scores of 16.0 and 11.2, respectively; P = 0.03) and sensation to pinprick (change scores of 11.4 and 6.6; P = 0.02) and touch (change scores, 8.9 and 4.3; P = 0.03). Benefit from methylprednisolone was seen in patients whose injuries were initially evaluated as neurologically complete, as well as in those believed to have incomplete lesions .
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In VitroMethylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Methylprednisolone is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used for vestibular neuritis .After six months the patients who were treated with methylprednisolone within eight hours of their injury had significant improvement as compared with those given placebo in motor function (neurologic change scores of 16.0 and 11.2, respectively; P = 0.03) and sensation to pinprick (change scores of 11.4 and 6.6; P = 0.02) and touch (change scores, 8.9 and 4.3; P = 0.03). Benefit from methylprednisolone was seen in patients whose injuries were initially evaluated as neurologically complete, as well as in those believed to have incomplete lesions .
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In Vivo——
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SynonymsMedesone | Medrol | Noretona | NSC 19987 | U 7532
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PathwayEndocrinology/Hormones
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TargetGR
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RecptorGlucocorticoid Receptor
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number83-43-2
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Formula Weight374.48
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Molecular FormulaC22H30O5
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Purity>98% (HPLC)
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SolubilityEthanol: 2 mg/mL (5.34 mM); DMSO: 75 mg/mL (200.28 mM)
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SMILESC[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
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Chemical Name(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Owen HC, et al. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70.
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