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Mertansine

CAS No. 139504-50-0

Mertansine ( DM1;Maytansinoid DM1;DM-1;Maytansinoid DM-1 )

Catalog No. M11649 CAS No. 139504-50-0

Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC); an ADC payload.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mertansine
  • Note
    Research use only, not for human use.
  • Brief Description
    Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC); an ADC payload.
  • Description
    Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC); an ADC payload.
  • Synonyms
    DM1;Maytansinoid DM1;DM-1;Maytansinoid DM-1
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADC Cytotoxin
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    139504-50-0
  • Formula Weight
    738.29
  • Molecular Formula
    C35H48ClN3O10S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 83.33 mg/mL
  • SMILES
    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C\C=C(\CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@H]([C@]4(C1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)/C)OC)(NC(=O)O2)O
  • Chemical Name
    Maytansine, N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Niculescu-Duvaz I. Curr Opin Mol Ther. 2010 Jun;12(3):350-60.
2. Lambert JM. Br J Clin Pharmacol. 2013 Aug;76(2):248-62.
3. Helft PR, et al. Clin Cancer Res. 2004 Jul 1;10(13):4363-8.
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