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Daunorubicin

CAS No. 20830-81-3

Daunorubicin ( RP13057;Daunomycin;Rubidomycin )

Catalog No. M13246 CAS No. 20830-81-3

Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Daunorubicin
  • Note
    Research use only, not for human use.
  • Brief Description
    Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.
  • Description
    Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells; Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma; Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).Chemotherapeutic Agents Approved
  • Synonyms
    RP13057;Daunomycin;Rubidomycin
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADC Cytotoxin
  • Recptor
    ADC Cytotoxin
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    20830-81-3
  • Formula Weight
    527.52
  • Molecular Formula
    C27H29NO10
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O
  • Chemical Name
    5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Latif ZA, et al. Cancer. 1980 Mar 15;45(6):1326-33.
2. Hurwitz E, et al. Int J Cancer. 1979 Oct 15;24(4):461-70.
3. Aboud-Pirak E, et al. Proc Natl Acad Sci U S A. 1989 May;86(10):3778-81.
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