Menadione

Research use only, not for human use.

Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

Cell Proliferation Assay Cell Line:AR4-2J cells Concentration:0-100 μM Incubation Time:24-72 h Result:Inhibited cell proliferation in time- and dose-dependently manner at lower concentrations (1-20 μM).Western Blot Analysis Cell Line:AR4-2J cells Concentration:0-100 μM Incubation Time:24 h Result:Induced wild-type P53 at the dose of 1-20 μM.Induced a low level of wild-type P53 at the dose of 100 μM.

Animal Model:Male Wister ratsDosage:25-150 mg/kg Administration:i.v., once time or every other day for five times Result:Showed microgranular degeneration of renal tubular cells at the dose of 25 mg/kg.Observed microgranular degeneration of renal tubular cells and mild pulmonary hemorrhage at the dose of 50 mg/kg.Produced lesions in the kidney, heart, liver and lung at the dose of 100-150 mg/kg.Showed kidney apoptosis at the dose of 100-150 mg/kg.

Menadione | NSC 4170

Autophagy

Thrombin

Thrombin| VK

Other Indications

——

58-27-5

172.18

C11H8O2

>98% (HPLC)

Ethanol: 34 mg/mL (197.46 mM); DMSO: 34 mg/mL (197.46 mM)

CC1=CC(=O)C2=CC=CC=C2C1=O

2-methylnaphthalene-1,4-dione

(-20℃)

With Ice Pack

≥ 2 years