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Flovagatran
CAS No. 871576-03-3
Flovagatran( —— )
Catalog No. M34600 CAS No. 871576-03-3
Flovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 1158 | Get Quote |
|
| 5MG | 1511 | Get Quote |
|
| 10MG | 1881 | Get Quote |
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| 50MG | 2374 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameFlovagatran
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NoteResearch use only, not for human use.
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Brief DescriptionFlovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.
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DescriptionFlovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
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In Vitro——
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In VivoFlovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs.Animal Model:Chicks Dosage:1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes.2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes.5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes.Administration:Bolus plus infusion Result:Elevated PD markers, and produced minimal post-operative blood loss.
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Synonyms——
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PathwayAutophagy
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TargetThrombin
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RecptorThrombin
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Research Area——
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Indication——
Chemical Information
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CAS Number871576-03-3
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Formula Weight525.4
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Molecular FormulaC27H36BN3O7
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Purity>98% (HPLC)
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Solubility——
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SMILESC([C@@H](CC1=CC=CC=C1)NC(OCC2=CC=CC=C2)=O)(=O)N3[C@H](C(N[C@@H](CCCOC)B(O)O)=O)CCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nelson DA, et al. Pharmacodynamic and efficacy profile of TGN 255, a novel direct thrombin inhibitor, in canine cardiopulmonary bypass and simulated mitral valve repair. J Extra Corpor Technol. 2008 Jun;40(2):116-22. ?
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