Cart
sales@molnova.com
Home - Products - Autophagy - Thrombin - Flovagatran

Flovagatran

CAS No. 871576-03-3

Flovagatran( —— )

Catalog No. M34600 CAS No. 871576-03-3

Flovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 1158 Get Quote
5MG 1511 Get Quote
10MG 1881 Get Quote
50MG 2374 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Flovagatran
  • Note
    Research use only, not for human use.
  • Brief Description
    Flovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.
  • Description
    Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
  • In Vitro
    ——
  • In Vivo
    Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs.Animal Model:Chicks Dosage:1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes.2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes.5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes.Administration:Bolus plus infusion Result:Elevated PD markers, and produced minimal post-operative blood loss.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Thrombin
  • Recptor
    Thrombin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    871576-03-3
  • Formula Weight
    525.4
  • Molecular Formula
    C27H36BN3O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C([C@@H](CC1=CC=CC=C1)NC(OCC2=CC=CC=C2)=O)(=O)N3[C@H](C(N[C@@H](CCCOC)B(O)O)=O)CCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nelson DA, et al. Pharmacodynamic and efficacy profile of TGN 255, a novel direct thrombin inhibitor, in canine cardiopulmonary bypass and simulated mitral valve repair. J Extra Corpor Technol. 2008 Jun;40(2):116-22. ?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Dabigatran etexilate...

    A prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM.

  • Imitrodast

    Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiovascular diseases, and can be used in studies of arterial thrombosis, asthma, and coronary vasospasm.

  • Efegatran sulfate

    Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.

Sign In Join Free