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Melphalan

CAS No. 148-82-3

Melphalan ( L-PAM )

Catalog No. M12056 CAS No. 148-82-3

A chemotherapy agent that acts through alkylation of the DNA nucleotide guanine, and causes linkages between strands of DNA; inhibits DNA synthesis and RNA synthesis in both dividing and non-dividing tumor cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Melphalan
  • Note
    Research use only, not for human use.
  • Brief Description
    A chemotherapy agent that acts through alkylation of the DNA nucleotide guanine, and causes linkages between strands of DNA; inhibits DNA synthesis and RNA synthesis in both dividing and non-dividing tumor cells.
  • Description
    A chemotherapy agent that acts through alkylation of the DNA nucleotide guanine, and causes linkages between strands of DNA; inhibits DNA synthesis and RNA synthesis in both dividing and non-dividing tumor cells. Chemotherapeutic Agents Approved
  • Synonyms
    L-PAM
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    DNA Alkylator
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    148-82-3
  • Formula Weight
    305.20
  • Molecular Formula
    C13H18Cl2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: < 9.2 mg/mL
  • SMILES
    N[C@@H](CC1=CC=C(N(CCCl)CCCl)C=C1)C(O)=O
  • Chemical Name
    L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dudek-Peri AM, et al. Cancer Res. 2015 Apr 15;75(8):1603-14.
2. Keane MM, et al. Cancer Res. 1999 Feb 1;59(3):734-41.
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