Macozinone

CAS No. 1377239-83-2

Macozinone ( PBTZ169;PBTZ-169 )

Catalog No. M11559 CAS No. 1377239-83-2

Macozinone (PBTZ-169, PBTZ169)is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 57 In Stock
5MG 102 In Stock
10MG 162 In Stock
25MG 324 In Stock
50MG 502 In Stock
100MG 718 In Stock
500MG 1431 In Stock
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Biological Information

  • Product Name
    Macozinone
  • Note
    Research use only, not for human use.
  • Brief Description
    Macozinone (PBTZ-169, PBTZ169)is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
  • Description
    Macozinone (PBTZ-169, PBTZ169)is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.Bacterial Infection Phase 2 Clinical
  • Synonyms
    PBTZ169;PBTZ-169
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    DprE1
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1377239-83-2
  • Formula Weight
    456.48
  • Molecular Formula
    C20H23F3N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 6.4 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
  • Chemical Name
    2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Makarov V, et al. EMBO Mol Med. 2014 Mar;6(3):372-83.
2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.
3. González-Martínez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.
4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63.
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