KKL-10 ( KKL10 )

Catalog No. M16811 CAS No. 952849-76-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KKL-10
Note

Research use only, not for human use.
Brief Description

KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
Description

KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture; exhibits exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.48 ug/mL, respectively; arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.
Synonyms

KKL10
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

ribosomerescue
Research Area

——
Indication

——

CAS Number

952849-76-2
Formula Weight

364.22
Molecular Formula

4H10BrN3O2S
Purity

>98% (HPLC)
Solubility

DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(C1=CC=C(Br)S1)NC2=NN=C(C3=CC=C(C)C=C3)O2
Chemical Name

5-Bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]-2-thiophenecarboxamide

1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.

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