MU1210 ( MU-1210;MU 1210 )

Catalog No. M13620 CAS No. 2275601-87-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MU1210
Note

Research use only, not for human use.
Brief Description

MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM.
Description

MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1); profoundly affected the Mdm4 alternative splicing and showed high activity in cytotoxicity assays using MCF7 breast cancer cells; MU1210 has favorable pharmacokinetics (mouse, 10 mpk, IP: Cmax =1.24 mm, T1/2 = 58 min; no acute toxicity observed), suggesting its potential use in in vivo models; MU1210 is a quality probe for CLK1, CLK2, and CLK4.
Synonyms

MU-1210;MU 1210
Pathway

Cell Cycle/DNA Damage
Target

CLK
Recptor

CLK
Research Area

——
Indication

——

CAS Number

2275601-87-9
Formula Weight

352.40
Molecular Formula

C22H16N4O
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

5-(1-methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-4-yl)phenyl)furo[3,2-b]pyridine

1. Němec V, et al. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066.

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