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SRI-29329
CAS No. 2086809-58-5
SRI-29329( SRI29329 | SRI 29329 )
Catalog No. M13252 CAS No. 2086809-58-5
A potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and4, respectively; shows no significant activity for CLK3, CDK1, CDK4 and CDK6 (IC50>1,000 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 178 | Get Quote |
|
| 10MG | 291 | Get Quote |
|
| 25MG | 492 | Get Quote |
|
| 50MG | 709 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSRI-29329
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and4, respectively; shows no significant activity for CLK3, CDK1, CDK4 and CDK6 (IC50>1,000 nM).
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DescriptionA potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and4, respectively; shows no significant activity for CLK3, CDK1, CDK4 and CDK6 (IC50>1,000 nM).
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In VitroSRI-29329 (compound 8) shows some modest (~5 fold) selectivity for CLK2 over CLK1 and CLK4 without significant CDK1,4,6 activity.
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In Vivo——
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SynonymsSRI29329 | SRI 29329
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PathwayCell Cycle/DNA Damage
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TargetCLK
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RecptorCLK
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Research Area——
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Indication——
Chemical Information
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CAS Number2086809-58-5
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Formula Weight399.927
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Molecular FormulaC20H26ClN7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (125.03 mM)
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SMILESCC(N1C=NC2=C(NC3=CC=CC(Cl)=C3)N=C(N[C@@H]4[C@@H](N)CCCC4)N=C12)C
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Chemical NameN2-((1S,2S)-2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-isopropyl-9H-purine-2,6-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.
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