MS-023 ( MS023;MS 023 )

Catalog No. M12819 CAS No. 1831110-54-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MS-023
Note

Research use only, not for human use.
Brief Description

MS-023 is a potent, selective, and cell-active inhibitor of type I PRMTs with IC50s of 30/119/83/4/5 nM for PRMT1/3/4/6/8 respectively.
Description

MS-023 is a potent, selective, and cell-active inhibitor of type I PRMTs with IC50s of 30/119/83/4/5 nM for PRMT1/3/4/6/8 respectively; doesn't inhibit PRMT5/9/7(>10 uM); inhibits H4R3me2a and H3R2me2a levels in MCF7 cells.
Synonyms

MS023;MS 023
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

PRMT1;PRMT3;PRMT4;PRMT6;PRMT8
Research Area

Other Indications
Indication

——

CAS Number

1831110-54-3
Formula Weight

287.40
Molecular Formula

C17H25N3O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

CC(C)OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN
Chemical Name

1,2-Ethanediamine, N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-

1. Eram MS, et al. ACS Chem Biol. 2016 Mar 18;11(3):772-81.

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