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MRS-1706
CAS No. 264622-53-9
MRS-1706( —— )
Catalog No. M24174 CAS No. 264622-53-9
MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 110 | In Stock |
|
| 25MG | 228 | In Stock |
|
| 50MG | 447 | In Stock |
|
| 100MG | 651 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMRS-1706
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NoteResearch use only, not for human use.
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Brief DescriptionMRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist.
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DescriptionMRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist.
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In VitroMRS-1706 (0.1-5 μM) has antagonist effect of NECA on the wild-type adenosine A2B receptor in a dose-dependent manner.MRS-1706 (0.1-10000 nM) induces inhibition of yeast growth, which yeast cells expressing seven CAM adenosine A2B receptors, with IC50 values of 43, 54, 40, 98, 166, 133 nM for F84L, F84S, F84L/S95G, T42A, T42A/V54A, N36S/T42A, respectively.MRS-1706 (1 μM) inhibits the adenosine-mediated induction of cAMP in wild-type corpus cavernosal strips (CCSs) and decreases the level of cAMP.
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In VivoMRS-1706 (1-10 μM; intracavernous injection; Ada–/– mice) reduces the magnitude and duration of electrical field stimulation (EFS)-induced contraction of corpus cavernosal strips (CCSs) from sickle cell disease (SCD) transgenic mice and inhibits the level of cAMP. Animal Model:Ada–/–mice Dosage:1 and 10 μM Administration:Intracavernous injection Result:Inhibited A2BR signaling and reduced the magnitude and duration.Inhibited the level of cAMP.
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Synonyms——
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorA1|A2A|A2B|A3
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Research Area——
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Indication——
Chemical Information
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CAS Number264622-53-9
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Formula Weight503.55
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Molecular FormulaC27H29N5O5
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Purity>98% (HPLC)
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SolubilityDMSO:6.4 mg/mL (12.71 mM; Need ultrasonic and warming);H2O:< 0.1 mg/mL (insoluble)
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SMILESO=C(NC1=CC=C(C(C)=O)C=C1)COC2=CC=C(C3=NC(N(CCC)C(N(CCC)C4=O)=O)=C4N3)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Li Q, et al. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J Pharmacol Exp Ther. 2007 Feb;320(2):637-45.
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