Cart
sales@molnova.com
Tonapofylline
CAS No. 340021-17-2
Tonapofylline( BG 9928 | BG9928 )
Catalog No. M14153 CAS No. 340021-17-2
A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | Get Quote |
|
| 10MG | 213 | Get Quote |
|
| 25MG | 428 | Get Quote |
|
| 50MG | 622 | Get Quote |
|
| 100MG | 885 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTonapofylline
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
-
DescriptionA potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM; displays 915-foldselectivity over A2A receptor, 12-fold over A2B receptor; increases sodium excretion and cause natriuresis without causing kaliuresis or reducing renal function.Heart Failure Phase 2 Discontinued.
-
In Vitro——
-
In VivoAnimal Model:Female viral antigen-free Sprague-Dawley rats Dosage:1 mg/kg Administration:Oral administration; twice a day, days 0-6 Result:Produced sustained reductions in post-NSC 119875 serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of NSC 119875-induced (5.5 mg/kg) kidney pathology scores.
-
SynonymsBG 9928 | BG9928
-
PathwayApoptosis
-
TargetAdenosine Receptor
-
RecptorAdenosine Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number340021-17-2
-
Formula Weight416.522
-
Molecular FormulaC22H32N4O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (240.09 mM)
-
SMILESO=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1
-
Chemical Name1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Auchampach JA, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):846-56.
2. Kiesman WF, et al. J Med Chem. 2006 Nov 30;49(24):7119-31.
3. Greenberg B, et al. J Am Coll Cardiol. 2007 Aug 14;50(7):600-6.
molnova catalog
related products
-
MRS-1706
MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B receptor inverse agonist.
-
Xanthine amine conge...
Xanthine amine congener trihydrochloride is a potent adenosine antagonist that reverses the reduction in urine flow, sodium excretion and heart rate produced by the adenosine agonist, N6-cyclohexyladenosine.
-
Vipadenant
A potent and selective A2A adenosine receptor with Ki of 1.3 nM.
