Tonapofylline

CAS No. 340021-17-2

Tonapofylline( BG 9928 | BG9928 )

Catalog No. M14153 CAS No. 340021-17-2

A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 132 Get Quote
10MG 213 Get Quote
25MG 428 Get Quote
50MG 622 Get Quote
100MG 885 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Tonapofylline
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
  • Description
    A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM; displays 915-foldselectivity over A2A receptor, 12-fold over A2B receptor; increases sodium excretion and cause natriuresis without causing kaliuresis or reducing renal function.Heart Failure Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female viral antigen-free Sprague-Dawley rats Dosage:1 mg/kg Administration:Oral administration; twice a day, days 0-6 Result:Produced sustained reductions in post-NSC 119875 serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of NSC 119875-induced (5.5 mg/kg) kidney pathology scores.
  • Synonyms
    BG 9928 | BG9928
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    340021-17-2
  • Formula Weight
    416.522
  • Molecular Formula
    C22H32N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (240.09 mM)
  • SMILES
    O=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1
  • Chemical Name
    1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Auchampach JA, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):846-56. 2. Kiesman WF, et al. J Med Chem. 2006 Nov 30;49(24):7119-31. 3. Greenberg B, et al. J Am Coll Cardiol. 2007 Aug 14;50(7):600-6.
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