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Tonapofylline

CAS No. 340021-17-2

Tonapofylline( BG 9928 | BG9928 )

Catalog No. M14153 CAS No. 340021-17-2

A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tonapofylline
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
  • Description
    A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM; displays 915-foldselectivity over A2A receptor, 12-fold over A2B receptor; increases sodium excretion and cause natriuresis without causing kaliuresis or reducing renal function.Heart Failure Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female viral antigen-free Sprague-Dawley rats Dosage:1 mg/kg Administration:Oral administration; twice a day, days 0-6 Result:Produced sustained reductions in post-NSC 119875 serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of NSC 119875-induced (5.5 mg/kg) kidney pathology scores.
  • Synonyms
    BG 9928 | BG9928
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    340021-17-2
  • Formula Weight
    416.522
  • Molecular Formula
    C22H32N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (240.09 mM)
  • SMILES
    O=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1
  • Chemical Name
    1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Auchampach JA, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):846-56. 2. Kiesman WF, et al. J Med Chem. 2006 Nov 30;49(24):7119-31. 3. Greenberg B, et al. J Am Coll Cardiol. 2007 Aug 14;50(7):600-6.
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