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CAY-10603
CAS No. 1045792-66-2
CAY-10603 ( CAY10603 )
Catalog No. M10225 CAS No. 1045792-66-2
A highly potent and selective HDAC6 inhibitor with IC50 of 2 pM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 68 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 156 | In Stock |
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| 25MG | 291 | In Stock |
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| 50MG | 492 | In Stock |
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| 100MG | 709 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCAY-10603
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and selective HDAC6 inhibitor with IC50 of 2 pM.
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DescriptionA highly potent and selective HDAC6 inhibitor with IC50 of 2 pM; 200-fold less potent for HDAC3 (IC50=0.42 nM) and no inhibition on HDAC1/2/8/10 (IC50> 100 nM); downregulates the levels of EGFR protein and synergizes with gefitinib to induce apoptosis of the lung adenocarcinoma cell lines.
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SynonymsCAY10603
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC6
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1045792-66-2
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Formula Weight446.50
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Molecular FormulaC22H30N4O6
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(OC(C)(C)C)NC1=CC=C(C2=CC(C(NCCCCCCC(NO)=O)=O)=NO2)C=C1
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Chemical NameCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kozikowski AP, et al. J Med Chem. 2008 Aug 14;51(15):4370-3.
2. Wang Z, et al. Oncol Rep. 2016 Jul;36(1):589-97.
2. Wang Z, et al. Oncol Rep. 2016 Jul;36(1):589-97.
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