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MMRi64
CAS No. 430458-66-5
MMRi64( MMRi64 )
Catalog No. M14460 CAS No. 430458-66-5
MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | Get Quote |
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| 10MG | 174 | Get Quote |
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| 25MG | 300 | Get Quote |
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| 50MG | 447 | Get Quote |
|
| 100MG | 624 | Get Quote |
|
| 500MG | 1305 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMMRi64
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NoteResearch use only, not for human use.
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Brief DescriptionMMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.
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DescriptionMMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a.
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In Vitro——
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In Vivo——
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SynonymsMMRi64
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number430458-66-5
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Formula Weight410.298
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Molecular FormulaC22H17Cl2N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (243.72 mM)
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SMILESOC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(Cl)=C3Cl)NC4=NC=CC(C)=C4
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Chemical Name7-[(2,3-Dichlorophenyl)[(4-methyl-2-pyridinyl)amino]methyl]-8-quinolinol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035.
molnova catalog
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DIMP53-1
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