MM-206 ( MM206;MM 206 )

Catalog No. M12775 CAS No. 1809581-87-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MM-206
Note

Research use only, not for human use.
Brief Description

A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM.
Description

A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD); also inhibits G-CSF-induced STAT3 phosphorylation in AML cell lines with IC50 of 0.8-1.9 uM,
Synonyms

MM206;MM 206
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

CAS Number

1809581-87-0
Formula Weight

497.45
Molecular Formula

C22H12F5NO3S2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=C(F)C(F)=C(F)C(F)=C1F)(NC2=C3C=CC=CC3=C(O)C(SC4=CC=CC=C4)=C2)=O
Chemical Name

2,3,4,5,6-pentafluoro-N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)benzenesulfonamide

1. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9.

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