
MLT-747
CAS No. 2097853-86-4
MLT-747( MLT747 | MLT 747 )
Catalog No. M13311 CAS No. 2097853-86-4
MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 262 | Get Quote |
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50MG | 1341 | Get Quote |
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100MG | 2124 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameMLT-747
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NoteResearch use only, not for human use.
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Brief DescriptionMLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket.
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DescriptionMLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket, reversibly binds and stabilizes human mutant MALT1-W580S in vitro and in MALT1mut/mut B cells, inhibits MALT1 peptide cleavage.
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In VitroMLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM.
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In Vivo——
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SynonymsMLT747 | MLT 747
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase
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Research Area——
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Indication——
Chemical Information
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CAS Number2097853-86-4
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Formula Weight478.334
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Molecular FormulaC20H21Cl2N7O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (209.06 mM)
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SMILESO=C(NC1=CC(Cl)=C(C(N2CCCC2)=O)N=C1)NC3=C([C@@H](OC)C)N4C(N=C3)=CC(Cl)=N4
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Chemical Name(S)-1-(5-chloro-6-(pyrrolidine-1-carbonyl)pyridin-3-yl)-3-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Quancard J, et al. Nat Chem Biol. 2019 Jan 28. doi: 10.1038/s41589-018-0222-1.
molnova catalog



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