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Home - Products - Apoptosis - Caspase - MLT-747

MLT-747

CAS No. 2097853-86-4

MLT-747( MLT747 | MLT 747 )

Catalog No. M13311 CAS No. 2097853-86-4

MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MLT-747
  • Note
    Research use only, not for human use.
  • Brief Description
    MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket.
  • Description
    MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket, reversibly binds and stabilizes human mutant MALT1-W580S in vitro and in MALT1mut/mut B cells, inhibits MALT1 peptide cleavage.
  • In Vitro
    MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM.
  • In Vivo
    ——
  • Synonyms
    MLT747 | MLT 747
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2097853-86-4
  • Formula Weight
    478.334
  • Molecular Formula
    C20H21Cl2N7O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (209.06 mM)
  • SMILES
    O=C(NC1=CC(Cl)=C(C(N2CCCC2)=O)N=C1)NC3=C([C@@H](OC)C)N4C(N=C3)=CC(Cl)=N4
  • Chemical Name
    (S)-1-(5-chloro-6-(pyrrolidine-1-carbonyl)pyridin-3-yl)-3-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Quancard J, et al. Nat Chem Biol. 2019 Jan 28. doi: 10.1038/s41589-018-0222-1.
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