MLS0315771

Research use only, not for human use.

MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect.

MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 enhances mannose flux toward glycosylation. It ~50% of embryos appeared sick within 20 min at 8-10 μM, and most of them die by 30-60 min.

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Others

Other Targets

MPI

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727664-91-7

273.33

C15H12FNOS

>98% (HPLC)

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Cc1ccc(C)c(c1)-n1sc2cc(F)ccc2c1=O

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(-20℃)

With Ice Pack

≥ 2 years